Ampicillin for angina in adults and children: how to take it and how is it safe

Ampicillin in angina today continues to be actively used, despite the availability of much more effective and convenient antibiotics on the market, as well as skeptical attitude towards ampicillin from many doctors.

Like many semisynthetic penicillins of the first generation, ampicillin is highly effective for controlling the pathogens of strep throat - streptococcus and staphylococcus. At least with those strains that have not developed resistance to penicillins.

Most often ampicillin is used for angina in adults, but due to its safety, it is often prescribed to children, sometimes it is prescribed to pregnant women. However, all patients need to understand that in general, ampicillin and its drugs are the second choice in the treatment of angina, and for the appointment of a doctor should be a good reason. What does it mean?

How effective is ampicillin in angina, can it be taken and on what result should it be counted?

According to the effect on bacteria - pathogens of angina, ampicillin differs little from amoxicillin, phenoxymelite penicillin and other penicillins. Like all antibiotics of this group, getting with blood flow to the breeding ground of bacteria, ampicillin inhibits the synthesis of proteins that bacteria use to build and repair the cell wall.

Details about the treatment of angina with antibiotics

Accordingly, with proper use of the drug, the infection first stops developing, as the bacteria can not grow and divide, and then quickly dies when already existing bacteria die with permanent damage to their cell walls and their inability to recover.

Streptococcal cells with a strong increase

In practice, after 1-2 days of taking ampicillin, the patient feels considerable relief, after 4-5 days almost all symptoms of the disease can pass. These terms, however, are not rigid - in each specific case they may vary depending on the general condition of the patient's organism and on compliance with the instructions of the doctor, and in case of angina in the child - from his age.

In most cases, instead of ampicillin, doctors prefer to prescribe amoxicillin and its drugs. This is due to the fact that:

1. Ampicillin inferior to bioavailability of amoxicillin. Bioavailability of it - about 40%, amoxicillin - 93%. This means that if you drink a tablet of ampicillin with a substance content of 100 mg, only 40 mg will enter the blood. Of the same pill amoxicillin in the blood will get already 93 mg.

2. Ampicillin binds more fully to blood proteins, that is, even from that part of it that enters the blood, another 22% is inactivated. For amoxicillin, the amount of such an inactivated antibiotic is about 17%.

As a result, tablets with ampicillin or other forms of it for ingestion are inferior in effectiveness to analogues with amoxicillin, and the appointment of this antibiotic in many cases is not the optimal solution.

Combined preparation of ampicillin and sulbactam
Combined preparation of ampicillin and sulbactam

At the same time, it is possible to administer ampicillin in the form of intramuscular injections. In this case, those 40% of the drug, which are lost when the drug is absorbed from the stomach into the blood, actively affect the infection. But the very use of injections is much more labor-intensive (especially when it comes to treatment at home), and the same amoxicillin is absorbed into the blood at oral intake at about the same rate as ampicillin is absorbed from the muscles by injection. That is, in this case, this antibiotic is inferior to amoxicillin.

For all these reasons, ampicillin in angina in children and adults is used rarely. It is mainly used when amoxicillin preparations are not available.

In general, you can drink apicillin with angina, but only if it is reasonably recommended by a doctor. But even if the doctor prescribes ampicillin to drink with angina, it is worth to clarify with him, for what reason he appoints him, and not amoxicillin.

On a note!

Both amoxicillin and ampicillin are penicillins, both of which do not affect bacteria that produce pecillinase. Therefore, if in a particular case the bacteria are stable, for example, to amoxicillin, then ampicillin does not work on them. And vice versa. Likewise, if you drink ampicillin with angina, you can not because of the patient's allergies to penicillins, then amoxicillin is contraindicated. All this means that there are practically no situations when ampicillin can be prescribed, and more effective and preferred amoxicillin is not.

spatial model of the ampicillin molecule
The spatial model of the ampicillin molecule

Ampicillin preparations for the treatment of angina and form of the remedy

There are two main types of ampicillin drugs that are used to treat sore throats:

1. Preparations based on a single ampicillin;

2. Preparations based on ampicillin and sulbactam.

The addition of sulbactam in the drug expands the use of ampicillin in angina, as this drug neutralizes the protection of some bacteria resistant to ampicillin. At the same time, the sulbactam itself does not exert significant antibacterial action, and therefore the effectiveness of the drugs of the second group against angina is similar to that of antibiotic alone.

Preparations with sulbactam simply increase the chance that treatment will be effective in each case.

formula of sulbactam
The formula of sulbactam

Staphylococcus aureus
Staphylococcus aureus is one of the bacteria that causes angina

Rules for the use of ampicillin in angina

The course of treatment of angina with ampicillin should last at least 7 days. This is the minimum period that is sufficient to completely eliminate the infection and prevent recurrence. In case of severe illness or slow weakening of symptoms after the beginning of the appointment, the doctor may decide to extend the course to 15 days, and in rare cases - up to 2-3 weeks.

It is strictly forbidden to interrupt or shorten the period of treatment of angina with ampicillin without consulting the doctor. This can lead to the development of superinfection, complicating the disease and complicating its treatment.

With angina, a standard dosage of ampicillin is prescribed depending on the age of the patient:

1. Adults appoint 1 tablet (250 mg) 4 times a day for an hour before meals. The tablet should be washed down with water. In severe angina, a dose increase of 3 times is permitted;

2. Children under 1 year are prescribed ampicillin preparations in the form of suspensions. The dosage is 100 mg of the suspension for each kg of body weight per day. The daily portion is divided into 4-6 receptions;

3. Children from 1 year to 4 years, the daily volume of the drug is prepared based on the calculation of 100-150 mg of the suspension per kg of body weight. The daily norm is divided into 4-6 receptions;

4. In severe angina, children are prescribed ampicillin in the form of intramuscular injections (injections are done in the ass) with a dosage of 25-50 mg of the drug per kilogram of body weight 4 times a day.

Ampicillin in capsules form
Ampicillin in the form of capsules

Taking ampicillin during or after a meal is not recommended, because in this case, its absorption deteriorates.

It is strictly forbidden to rinse the mouth with a suspension of ampicillin or applying a tampon moistened with such a suspension to the tonsils. Such treatment can lead to the development of resistance in bacteria and a severe relapse of the disease. Antibiotic in angina can be taken only systemically.

In addition to taking ampicillin, it is possible to rinse the throat with various solutions, including antiseptic ones. The task of such auxiliary methods is to reduce the severity of symptoms in angina and alleviate the condition of the patient.

solution of furacilin for rinsing the throat
An auxiliary agent for the treatment of angina is a solution of furacilin for rinsing the throat

Ampicillin for pregnant women and breast-feeding mothers

In pregnancy, you can treat angina with ampicillin as directed by your doctor.

Ampicillin easily passes through the placenta and penetrates the fetus. However, it has no significant effects and does not affect the frequency of congenital anomalies in fetal development.

Nevertheless, it is recommended to avoid the appointment of ampicillin in the first trimester of pregnancy, and if necessary, use it in the minimum possible and justified from a therapeutic point of view. In late pregnancy, the drug is safe enough.

The half-life for ampicillin is about 1 hour. Approximately 4-5 hours after taking the drug, the amount of antibiotic in the body becomes negligible.

On a note! Ampicillin penetrates the placental barrier in much lesser amounts than amoxicillin. From this point of view, it is a more preferred drug, since with a weaker penetration into the fetal tissues, it is less likely to harm it.

Structural formula of ampicillin
Structural formula of ampicillin

Nevertheless, ampicillin in angina during pregnancy can be prescribed only by a doctor.

When breastfeeding, treat angina with ampicillin only if lactation is interrupted. The substance penetrates into breast milk and can cause dysbacteriosis and digestive disorders in the infant.

If you need to drink ampicillin with angina during lactation you need:

1. Transfer the baby to breastfeeding with a mixture or purchased breast milk from a bottle, and if possible - by breast from another mother. Breastmilk is preferable, because to the mixture the child quickly gets used to washing and refuses to drink breast milk after it. Just as quickly a child gets used to a bottle with a pacifier, from which it is much easier to suck;

2. When taking an antibiotic, continue to express the milk, so that its production does not stop;

3. After the end of taking ampicillin within two days, Polyphepan or its analogs are taken one tablespoon three times a day. After two days of such reception it is possible to renew feeding of the child by a breast.

Again, only a doctor should decide whether to stop lactation and prescribe ampicillin. Considering that at home many people put themselves a diagnosis of "angina" with viral infections, in some such cases, you do not need to take antibiotics at all.

Doctor prescribe the right treatment
Only a doctor, in view of his competence, can accurately identify the cause of pain in the throat and prescribe the right treatment.

Side effects and contraindications

Like all penicillins, ampicillin can cause a variety of side effects.

Among them:

- Headaches, cramps;

- Dysbacteriosis of the intestine, abdominal pain;

- Dyspeptic disorders: nausea, vomiting;

- Interstitial nephritis;

- Allergies, usually with itching and hives, allergic rhinitis, in exceptional cases - Quincke's edema and anaphylactic shock.

With the development of side effects, treatment should not be discontinued. In this case, it is necessary to contact the doctor to appoint an antibiotic of another group instead of ampicillin. An allergy to an antibiotic often occurs in adults, digestive disorders - in children.

Partly due to the presence of such side effects, in part because of the interaction with other drugs and the effect on various systems of organs, ampicillin is contraindicated in:

- Presence of hypersensitivity to penicillins in general;

- Presence of hypersensitivity to cephalosporins and carbapenems;

- Infectious mononucleosis;

- Hepatic insufficiency;

- Ulcerative colitis.

With care, ampicillin in angina is prescribed to patients with bronchial asthma, polyposis of the nose, pollinosis and kidney failure.

Sometimes, when taking ampicillin (especially if there is a violation of the rules for its use), an overdose with intoxication is possible. When it is made a gastric lavage, activated charcoal and accepted means to normalize the water-electrolyte balance.

Activated charcoal
Activated charcoal is recommended for various poisonings, including when overdosing ampicillin.


Ampicillin can be taken with angina, but it is rarely justified. It is more expedient to use amoxicillin instead. In any case, only a doctor can make a decision about the appointment of this antibiotic and only in the situation when the replacement of the same amoxicillin will be justified. You can not prescribe yourself and take ampicillin with angina.

Related pages:

Features of the most popular antibiotics used in angina
What is better to choose an antibiotic drug for angina?
Antibiotic for gastritis treatment
Amoxicillin for angina - when it was appointed?
Amoxil Description