Buy Amoxicillin 500mg Capsules Online

Amoxicillin 500mg - General information

Amoxicillin capsules substance Feature

Semisynthetic antibiotic penicillin group of broad-spectrum. Resistant to acids. Destroyed penicillinase. Amoxicillin. The molecular weight of 365.41. Amoxicillin sodium salt. The molecular weight of 387.89. Amoxicillin trihydrate. Solubility (mg / ml): 4.0 in water; 7.5 in methanol; 3.4 in absolute alcohol; insoluble in hexane, benzene, ethyl acetate, acetonitrile. The molecular weight of 419.45.

Amoxicillin 500mg: Pharmacology

Mode of action - antibacterial broad-spectrum bactericidal.

Inhibits transpeptidase, violates the synthesis of peptidoglycan (the reference protein of the cell wall) during the division and growth, causes lysis of microorganisms.

What is better to choose an antibiotic drug for angina?

It has a wide spectrum of antimicrobial action. It is active against aerobic Gram-positive microorganisms - Staphylococcus spp. (Except for strains producing penicillinase), Streptococcus spp., Including Streptococcus faecalis, Streptococcus pneumoniae, aerobic gram-negative organisms - Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Proteus mirabilis, Haemophilus influenzae, some strains of Salmonella, Shigella, Klebsiella, and Helicobacter pylori.

It operates on indolpolozhitelnye strains of Proteus (P.vulgaris, P.rettgeri); Serratia spp., Enterobacter spp., Morganella morganii, Pseudomonas spp. By its action resistant rickettsiae, mycoplasmas, viruses.

Ampicillin for angina in adults and children: how to take it and how is it safe

When administered as a suspension in doses of 125 mg / 5 mL and 250 mg / 5 ml fast and good (75-90%) is absorbed, creating Cmax (1,5-3,0 g / mL and 3.5-5, 0 .mu.g / ml, respectively) after 1-2 hours. When administered in capsules at doses of 250 and 500 mg Cmax (3,5-5,0 mg / ml and 5.5-7.5 mg / ml, respectively) also achieved in 1-2 hours. Stable under acidic conditions, it does not affect food intake on absorption.

When parenteral administration is rapidly absorbed and distributed in the tissues and body fluids; Cmax in the blood is detected 1 h after the / m and stored at therapeutic levels following parenteral administration for 6-8 hours.

Binding to plasma proteins is approximately 20%. Easily passes gistogematicalkie barriers, in addition to the unchanged BBB and penetrate quickly into most tissues and body fluids; accumulate at therapeutic concentrations in the peritoneal fluid, urine, content of skin blisters, pleural effusion, lung tissue, intestinal mucosa, female genital mutilation, the fluid of the middle ear, gall bladder and bile (with normal liver function), fetal tissues (it passes through the placental barrier ). T1 / 2 is 1-1.5 hours. In case of violation of renal function T1 / 2 extended to 4-12,6 hours, depending on the creatinine clearance. Partially metabolized to form inactive metabolites. 50-70% excreted by the kidneys unchanged by tubular secretion (80%) and glomerular filtration rate (20%), 10-20% - the liver. Trace amounts determined in the serum after 8 hours after ingestion. The small amount is excreted in breast milk.

Antibiotic for gastritis treatment


Symptoms include nausea, vomiting, diarrhea, disruption of water and electrolyte balance (a consequence of vomiting and diarrhea); long-term use at high doses - neurotoxic reactions and thrombocytopenia (these phenomena are reversible and disappear after discontinuation of the drug).

Treatment: gastric lavage, the appointment of activated carbon, saline laxatives, correction fluid and electrolyte balance; hemodialysis.

Amoxicillin 500mg capsules Dosage and Administration

Inside, in / m, / jet and drip. Before the appointment should be selected to determine the sensitivity of the pathogen. The dosage regimen is determined individually depending on the severity of the infection. Adults and children over 10 years (weighing over 40 kg) - inside, 500 mg 3 times a day (up to 0.75-1 g 3 times a day in severe infections); maximum daily dose - 6 g administered to children in the form of a suspension, the dose depends on the age, body weight and severity of the infection. The daily dose for children - 30 mg / kg (60 mg / kg), the multiplicity of reception - 2-3 times.

In acute uncomplicated gonorrhea - 3 g once (for women re-introduction is recommended).

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Patients with Cl creatinine below 10 ml / min, the dose is reduced by 15-50%, with anuria dose should not exceed 2 grams per day. The average exchange rate - 5-7 days (with streptococcal infections - not less than 10 days).

The / m, / jet and drip. When a single dose of greater than 2 g of the drug is introduced into / in the drip. The daily dose distribute 2-3 administration. The duration of the on / in 5-7 days, followed by a transition, if necessary, on the / m administration or ingestion of the drug. The duration of treatment depends on the type and severity of the disease and is 5-14 days or more.

Single dose for adults is 1-2 g is administered every 8-12 hours (3-6 g / day). Single dose for adults with the / m introduction should not exceed 1, the maximum daily dose for adults - 6 of infants born preterm, and children under 1 year administered in a daily dose of 100 mg / kg, for children of other age groups - 50 mg / kg . Single dose for children with the / m introduction - not more than 0,5 g In severe infections the dose for adults and children can be increased 1.5-2 times, in this case, the drug is introduced into / in. The daily dose distribute administration intervals of 2-3 hours 8-12.

In renal insufficiency, the treatment regimen is adjusted by reducing the dose or extending the interval between injections (24-48 h). When creatinine Cl 10-30 ml / min, the drug administered in a daily dose of 1 g, and then - by 0.5 g every 12 h; . If Cl creatinine less than 10 mL / min - 1 g, followed by 0.5 g every 24 hours in patients in a state of anuria daily dose should not exceed 2 in patients on hemodialysis, appoint an additional 2 g of the drug: 0.5 g during hemodialysis and 0.5 g after its completion.

Amoxicillin 500mg - special instructions

In patients with hypersensitivity to cephalosporins, carbapenems should consider the possibility of cross-allergies.

The role of amoxicillin in the treatment of common community-acquired infections

In severe infections of the gastrointestinal tract, accompanied by persistent diarrhea or vomiting should not be given Amoxicillin 500mg inside because of possible poor absorption.

The use of antibiotics is ineffective in the treatment of acute respiratory viral infections.

Particular caution should be exercised in patients with allergic diathesis or bronchial asthma and hay fever (hay fever), gastrointestinal disease in history (especially colitis, associated with the use of antibiotics).
Chronic administration of Amoxicillin 500mg capsules should appoint a Nystatin, Levorinum or other antifungals.

With prolonged use of high doses of the drug in patients should be monitored indicators of liver and kidney function, urine overall spending. It is advisable to control the picture of peripheral blood.

Drug interactions

Simultaneous use of the drug with probenecid leads to an increase in the blood concentration of amoxicillin by reducing its renal excretion. Thus Amoxicillin 500mg tissue penetration may be reduced.